Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Geminin and Brahma act antagonistically to regulate EGFR-Ras-MAPK signaling in Drosophila.

Developmental biology - 1 Aug 2010

Herr Anabel, Mckenzie Lisa, Suryadinata Randy, Sadowski Martin, Parsons Linda M, Sarcevic Boris, Richardson Helena E

Abstract excerpt

Geminin was identified in Xenopus as a dual function protein involved in the regulation of DNA replication and neural differentiation. In Xenopus, Geminin acts to antagonize the Brahma (Brm) chromatin-remodeling protein, Brg1, during neural differentiation. Here, we investigate the interaction of Geminin with the Brm complex during Drosophila development. We demonstrate that Drosophila Geminin (Gem) interacts...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Genetically Modified
Share to Cell Cycle Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drosophila Proteins

Share to MAP Kinase Signaling System

Share to ras Proteins

Share to RNA, Double-Stranded

Share to Trans-Activators

Share to Wings, Animal

Source

Identifiers

PMID: 20416294
DOI: 10.1016/j.ydbio.2010.04.006

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Geminin and Brahma act antagonistically to regulate EGFR-Ras-MAPK signaling in Drosophila.PMID 20416294Read ↗

Geminin loss causes neural tube defects through disrupted progenitor specification and neuronal differentiation.Semantic proximity Read ↗

The Drosophila ramshackle gene encodes a chromatin-associated protein required for cell morphology in the developing eye.Semantic proximity Read ↗

Direct interaction of geminin and Six3 in eye development.Semantic proximity Read ↗

Lin9, a subunit of the mammalian DREAM complex, is essential for embryonic development, for survival of adult mice, and for tumor suppression.Semantic proximity Read ↗

Par6G suppresses cell proliferation and is targeted by loss-of-function mutations in multiple cancers.Semantic proximity Read ↗

Genetic screens for enhancers of brahma reveal functional interactions between the BRM chromatin-remodeling complex and the delta-notch signal transduction pathway in Drosophila.Semantic proximity Read ↗

Geminin is essential for the development of preimplantation mouse embryosSemantic proximity Read ↗

Caenorhabditis elegans geminin homologue participates in cell cycle regulation and germ line development.Semantic proximity Read ↗

Fine-Tuning of the Actin Cytoskeleton and Cell Adhesion During Drosophila Development by the Unconventional Guanine Nucleotide Exchange Factors Myoblast City and Sponge.Semantic proximity Read ↗

Geminin deficiency causes a Chk1-dependent G2 arrest in Xenopus.Semantic proximity Read ↗

Drosophila PDZ-GEF, a guanine nucleotide exchange factor for Rap1 GTPase, reveals a novel upstream regulatory mechanism in the mitogen-activated protein kinase signaling pathway.Semantic proximity Read ↗

Receptor tyrosine phosphatase-dependent cytoskeletal remodeling by the hedgehog-responsive gene MIM/BEG4.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.