Article
HLA-DRB1 genotype influences risk for and severity of rheumatoid arthritis.
The Journal of rheumatology - 1 May 1999
Meyer J M, Evans T I, Small R E, Redford T W, Han J, Singh R, Moxley G
Abstract excerpt
OBJECTIVE: To examine how HLA-DRB1 genotypes influence rheumatoid arthritis (RA) risk and clinical severity. METHODS: We performed polymerase chain reaction based DRB1 and tumor necrosis factor (TNF) genotyping of 309 Caucasian RA and 283 Caucasian control subjects. For risk analyses, we grouped the DRB1 alleles encoding each specific shared epitope: *0401 alone, *0404 with *0102, *0405 with *0408 and *0101, and...
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