Article
A variant of HLA-DR4 determines susceptibility to rheumatoid arthritis in a subset of Israeli Jews.
Arthritis and rheumatism - 1 May 1991
Gao X J, Brautbar C, Gazit E, Segal R, Naparstek Y, Livneh A, Stastny P
Abstract excerpt
HLA-DR4 is associated with risk for developing rheumatoid arthritis (RA) in most populations. In Israeli Jews, in whom the Dw10 subtype of DR4 predominates, no association of RA with DR4 has been found. The inability to detect an association could be due to the high frequency of DR4-Dw10. We used DNA typing with amplification by the polymerase chain reaction and dot-blotting with allele-specific oligonucleotides...
Topics
- Alleles
- Arthritis, Rheumatoid
- Disease Susceptibility
- HLA-D Antigens
- HLA-DQ Antigens
- HLA-DR4 Antigen
- Humans
- Israel
- Jews
- Rheumatoid Factor