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Article

Compound heterozygosity for the shared epitope and the risk and severity of rheumatoid arthritis in extended pedigrees.

British journal of rheumatology - 1 Mar 1997

McDonagh J E, Dunn A, Ollier W E, Walker D J

Abstract excerpt

The objective was to explore the role of HLA-DRB1 genes in determining disease severity in rheumatoid arthritis (RA). The population comprised extended pedigrees of 17 multicase RA families. Family members were genotyped for both HLA-DRB1 alleles using restriction fragment length polymorphism (RFLP). Identification of HLA-DRB1*04 variants was performed using the Multiplex ARMS-RFLP technique. Compound...

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Identifiers

PMID: 9133963
DOI: 10.1093/rheumatology/36.3.322

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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