Article
Immunogenetic heterogeneity in rheumatoid disease as illustrated by different MHC associations (DQ, Dw and C4) in articular and extra-articular subsets.
British journal of rheumatology - 1 Feb 1991
Hillarby M C, Clarkson R, Grennan D M, Bate A S, Ollier W, Sanders P A, Chattophadhyay C, Davis M, O'Sullivan M M, Williams B
Abstract excerpt
Genetic variants at DRB1 (Dw subtypes), DQB, and C4 loci were compared in rheumatoid disease subjects with or without the extra-articular feature of Felty's syndrome or major vasculitis. DR4 positive subjects with rheumatoid arthritis alone showed no preferential associations with DQB or Dw varia...
Topics
- Alleles
- Amino Acid Sequence
- Arthritis, Rheumatoid
- Complement C4
- Felty Syndrome
- HLA-D Antigens
- HLA-DQ Antigens
- HLA-DR4 Antigen
- Haplotypes
- Humans
- Major Histocompatibility Complex