Article
At least two distinct epigenetic mechanisms are correlated with high-frequency "switching" for APRT phenotypic expression in mouse embryonal carcinoma stem cells.
Somatic cell and molecular genetics - 1 May 1992
Cooper G E, Khattar N H, Bishop P L, Turker M S
Abstract excerpt
A series of clones displaying high frequency "switching" phenotypes for expression of the adenine phosphoribosyltransferase (aprt) gene were previously isolated from the P19 mouse embryonal carcinoma stem cell line. Most clones contained only one aprt allele. We report here the characterization o...
Topics
- Adenine Phosphoribosyltransferase
- Animals
- Chromatin
- Dinucleoside Phosphates
- Embryonal Carcinoma Stem Cells
- Gene Expression Regulation, Enzymologic
- Genes, Switch
- Methylation
- Mice
- Neoplastic Stem Cells
- Phenotype
- RNA, Messenger
- Tumor Cells, Cultured