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Article

At least two distinct epigenetic mechanisms are correlated with high-frequency "switching" for APRT phenotypic expression in mouse embryonal carcinoma stem cells.

Somatic cell and molecular genetics - 1 May 1992

Cooper G E, Khattar N H, Bishop P L, Turker M S

Abstract excerpt

A series of clones displaying high frequency "switching" phenotypes for expression of the adenine phosphoribosyltransferase (aprt) gene were previously isolated from the P19 mouse embryonal carcinoma stem cell line. Most clones contained only one aprt allele. We report here the characterization of each of these clones with regards to enzymatic activity, mRNA steady state levels, DNA methylation, and chromatin...

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Source

Identifiers

PMID: 1496418
DOI: 10.1007/BF01233858

Genes

APRT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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At least two distinct epigenetic mechanisms are correlated with high-frequency "switching" for APRT phenotypic expression in mouse embryonal carcinoma stem cells.PMID 1496418Read ↗

Methylation of mouse adenine phosphoribosyltransferase gene is altered upon cellular differentiation and loss of phenotypic expression.Semantic proximity Read ↗

Molecular analysis of APRT deficiency in mouse P19 teratocarcinoma stem cell line.Semantic proximity Read ↗

Silencing of mouse Aprt is a gradual process in differentiated cells.Semantic proximity Read ↗

Heritable alterations at the adenine phosphoribosyltransferase (APRT) locus in human lymphoblastoid cell lines.Semantic proximity Read ↗

Aberrant epigenetic silencing is triggered by a transient reduction in gene expression.Semantic proximity Read ↗

Molecular and biochemical elucidation of a cellular phenotype characterized by adenine analogue resistance in the presence of high levels of adenine phosphoribosyltransferase activity.Semantic proximity Read ↗

A cell line selected for resistance to ionizing radiation exhibits cross resistance to other genotoxic agents and a mutator phenotype for loss of heterozygosity events.Semantic proximity Read ↗

Determination of spontaneous loss of heterozygosity mutations in Aprt heterozygous mice.Semantic proximity Read ↗

Endogenous gene systems for the study of mutational specificity in mammalian cells.Semantic proximity Read ↗

Allelic losses in mutations at the aprt locus of human lymphoblastoid cells.Semantic proximity Read ↗

Identification of mouse mutant cells exhibiting plastic mutant phenotype II; ionizing radiation-induced mutant phenotype plasticity is not dependent on DNA methylation of the hypoxanthine phosphoribosyl transferase gene in mouse FM3A cells.Semantic proximity Read ↗

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