Identification of mouse mutant cells exhibiting plastic mutant phenotype II; ionizing radiation-induced mutant phenotype plasticity is not dependent on DNA methylation of the hypoxanthine phosphoribosyl transferase gene in mouse FM3A cells.

Abstract excerpt

As we previously reported, we isolated and examined mouse mutant cells exhibiting phenotypic plasticity. Approximately 10% of 6-thioguanine resistant (6TG(R)) cells derived from the irradiated cell population exhibited phenotypic plasticity and reverted to wild type HAT resistance (HAT(R)). Similar mutant cells were also identified in an un-irradiated wild type cell population, but at a lower frequency. Ionizing...

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