Article
Allelic losses in mutations at the aprt locus of human lymphoblastoid cells.
Mutation research - 1 Sept 1992
Fujimori A, Tachibana A, Tatsumi K
Abstract excerpt
We analyzed the nature of mutations at the autosomal locus coding for adenine phosphoribosyltransferase (aprt) in human cells to elucidate the process(es) governing mutagenesis at autosomal loci. A human lymphoblastoid cell line, WR10, was found to be heterozygous for mutated allele at the aprt locus, and was used for mutation analyses. By the use of a restriction fragment length polymorphism associated with the...
Topics
- Adenine Phosphoribosyltransferase
- Alleles
- Base Sequence
- Blotting, Southern
- Cloning, Molecular
- Gamma Rays
- Genes, Tumor Suppressor
- Humans
- Molecular Sequence Data
- Mutagenesis
- Mutagenicity Tests