Article
Allelic losses in mutations at the aprt locus of human lymphoblastoid cells.
Mutation research - 1 Sept 1992
Fujimori A, Tachibana A, Tatsumi K
Abstract excerpt
We analyzed the nature of mutations at the autosomal locus coding for adenine phosphoribosyltransferase (aprt) in human cells to elucidate the process(es) governing mutagenesis at autosomal loci. A human lymphoblastoid cell line, WR10, was found to be heterozygous for mutated allele at the aprt locus, and was used for mutation analyses. By the use of a restriction fragment length polymorphism associated with the...
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