Article
Molecular and biochemical elucidation of a cellular phenotype characterized by adenine analogue resistance in the presence of high levels of adenine phosphoribosyltransferase activity.
Biochemical genetics - 1 Dec 1992
Khattar N H, Cooper G E, DiMartino D L, Bishop P L, Turker M S
Abstract excerpt
A mouse embryonal carcinoma cell line isolated for resistance to the adenine analogue 2,6-diaminopurine (DAP) was found to have near-wild-type levels of adenine phosphoribosyltransferase (APRT) activity in a cell-free assay. This DAP-resistant (DAPr) cell line, termed H29D1, also exhibited near-wild-type levels of adenine accumulation and the ability to grow in medium containing azaserine and adenine. Growth in...
Topics
- 2-Aminopurine
- Adenine
- Adenine Phosphoribosyltransferase
- Adenosine Monophosphate
- Amino Acid Sequence
- Animals
- Azaserine
- Base Sequence
- DNA Mutational Analysis
- Drug Resistance