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Article

Methylation of mouse adenine phosphoribosyltransferase gene is altered upon cellular differentiation and loss of phenotypic expression.

Somatic cell and molecular genetics - 1 Jul 1990

Turker M S

Abstract excerpt

Morphologically differentiated cell lines were previously isolated from a mouse teratocarcinoma stem cell line exhibiting an unstable heterozygous deficiency for adenine phosphoribosyltransferase (APRT) expression. In this study, the methylation sensitive and insensitive isoschizomer restriction endonucleases HpaII and MspI, respectively, were used to demonstrate that the aprt gene in the heterozygous deficient...

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PMID: 1699289
DOI: 10.1007/BF01232461

Genes

APRT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Methylation of mouse adenine phosphoribosyltransferase gene is altered upon cellular differentiation and loss of phenotypic expression.PMID 1699289Read ↗

At least two distinct epigenetic mechanisms are correlated with high-frequency "switching" for APRT phenotypic expression in mouse embryonal carcinoma stem cells.Semantic proximity Read ↗

Molecular analysis of APRT deficiency in mouse P19 teratocarcinoma stem cell line.Semantic proximity Read ↗

Silencing of mouse Aprt is a gradual process in differentiated cells.Semantic proximity Read ↗

Embryonic stem cells and somatic cells differ in mutation frequency and type.Semantic proximity Read ↗

The mouse APRT gene as a model for studying epigenetic gene inactivation.Semantic proximity Read ↗

Determination of spontaneous loss of heterozygosity mutations in Aprt heterozygous mice.Semantic proximity Read ↗

Loss of heterozygosity: the most frequent cause of recessive phenotype expression at the heterozygous human adenine phosphoribosyltransferase locus.Semantic proximity Read ↗

Identification of mouse mutant cells exhibiting plastic mutant phenotype II; ionizing radiation-induced mutant phenotype plasticity is not dependent on DNA methylation of the hypoxanthine phosphoribosyl transferase gene in mouse FM3A cells.Semantic proximity Read ↗

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Molecular and biochemical elucidation of a cellular phenotype characterized by adenine analogue resistance in the presence of high levels of adenine phosphoribosyltransferase activity.Semantic proximity Read ↗

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