Methylation of mouse adenine phosphoribosyltransferase gene is altered upon cellular differentiation and loss of phenotypic expression.

doi:10.1007/BF01232461

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Article

Methylation of mouse adenine phosphoribosyltransferase gene is altered upon cellular differentiation and loss of phenotypic expression.

Somatic cell and molecular genetics - 1 Jul 1990

Turker M S

Abstract excerpt

Morphologically differentiated cell lines were previously isolated from a mouse teratocarcinoma stem cell line exhibiting an unstable heterozygous deficiency for adenine phosphoribosyltransferase (APRT) expression. In this study, the methylation sensitive and insensitive isoschizomer restriction endonucleases HpaII and MspI, respectively, were used to demonstrate that the aprt gene in the heterozygous deficient...

Topics

Adenine Phosphoribosyltransferase
Animals
Cell Differentiation
Cell Line
DNA
Deoxyribonuclease HpaII
Deoxyribonucleases, Type II Site-Specific
Exons
Gene Expression Regulation, Enzymologic
Heterozygote

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Homozygote

Introns

Methylation

Mice

Phenotype

Stem Cells

Source

Open in PubMed

Identifiers

PMID: 1699289
DOI: 10.1007/BF01232461

Genes

APRT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1699289-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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