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Article

A cell line selected for resistance to ionizing radiation exhibits cross resistance to other genotoxic agents and a mutator phenotype for loss of heterozygosity events.

Somatic cell and molecular genetics - 1 Mar 1997

Walker K A, Jennings C D, Pulliam J, Ogburn C, Martin G M, Urano M, Turker M S

Abstract excerpt

An ionizing radiation resistant derivative was obtained from the mouse P19H22 (aprt hemizygote) embryonal carcinoma cell line by repeated exposure to 137Cs gamma radiation. Ionizing radiation resistance in the 6Gy-R cell line was not correlated with a failure to undergo cell cycle arrest or a los...

Topics

Adenine Phosphoribosyltransferase
Animals
Carcinoma, Embryonal
Cesium Radioisotopes
Chromosomes, Human, Pair 8
Clone Cells
Gamma Rays
Humans
Hypoxanthine Phosphoribosyltransferase
Loss of Heterozygosity
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutagens

Phenotype

Radiation Tolerance

Tetrahydrofolate Dehydrogenase

Tumor Cells, Cultured

Source

Identifiers

PMID: 9330639
DOI: 10.1007/BF02679970

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9330639-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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A cell line selected for resistance to ionizing radiation exhibits cross resistance to other genotoxic agents and a mutator phenotype for loss of heterozygosity events.PMID 9330639Read ↗

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