Heritable alterations at the adenine phosphoribosyltransferase (APRT) locus in human lymphoblastoid cell lines.

doi:10.1016/0027-5107(92)90013-r

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Article

Heritable alterations at the adenine phosphoribosyltransferase (APRT) locus in human lymphoblastoid cell lines.

Mutation research - 16 Dec 1992

Amundson S A, Fortunato J E, Liber H L

Abstract excerpt

Human lymphoblastoid cell lines derived from WI-L2 exhibit unexpected frequencies of diaminopurine (DAP) resistant mutants. The background mutant fractions of 10(-7) to 10(-8) in untreated cultures are much lower than the frequencies expected for loss of a heterozygous autosomal locus (10(-5) to 10(-6), yet much higher than expected for a homozygous locus (10(-10) to 10(-12). We used aminopterin, adenine and...

Topics

2-Aminopurine
Adenine Phosphoribosyltransferase
Aminacrine
Azacitidine
Blotting, Southern
Cell Line
DNA
Dose-Response Relationship, Drug
Dose-Response Relationship, Radiation
Drug Resistance
Ethyl Methanesulfonate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gene Frequency

Humans

Mutagens

Mutation

Nitrogen Mustard Compounds

X-Rays

Source

Open in PubMed

Identifiers

PMID: 1281280
DOI: 10.1016/0027-5107(92)90013-r

Genes

DAP
APRT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1281280-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Heritable alterations at the adenine phosphoribosyltransferase (APRT) locus in human lymphoblastoid cell lines.PMID 1281280Read ↗

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Reduction to homozygosity is the predominant spontaneous mutational event in cultured human lymphoblastoid cells.Semantic proximity Read ↗

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Germline and somatic mutations leading to adenine phosphoribosyltransferase (APRT) deficiency.Semantic proximity Read ↗

Molecular and biochemical elucidation of a cellular phenotype characterized by adenine analogue resistance in the presence of high levels of adenine phosphoribosyltransferase activity.Semantic proximity Read ↗

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