Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Aberrant epigenetic silencing is triggered by a transient reduction in gene expression.

PloS one - 1 Jan 2009

Oyer Jon A, Chu Adrian, Brar Sukhmani, Turker Mitchell S

Abstract excerpt

BACKGROUND: Aberrant epigenetic silencing plays a major role in cancer formation by inactivating tumor suppressor genes. While the endpoints of aberrant silencing are known, i.e., promoter region DNA methylation and altered histone modifications, the triggers of silencing are not known. We used the tet-off system to test the hypothesis that a transient reduction in gene expression will sensitize a promoter to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylation
Share to Culture Media
Share to DNA Primers

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Doxycycline

Share to Epigenesis, Genetic

Share to Gene Expression Regulation

Share to Gene Silencing

Share to Hypoxanthine Phosphoribosyltransferase

Source

Open in PubMed Open full text

Identifiers

PMID: 19279688
DOI: 10.1371/journal.pone.0004832
PMCID: PMC2654015

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Aberrant epigenetic silencing is triggered by a transient reduction in gene expression.PMID 19279688Read ↗

Evidence that silencing of the HPRT promoter by DNA methylation is mediated by critical CpG sites.Semantic proximity Read ↗

Reversing transgene silencing via targeted chromatin editingSemantic proximity Read ↗

Temporal Transcriptomics Identifies Isoform-specific Trans-regulation by Multiple lncRNAs in Human iPSCsSemantic proximity Read ↗

At least two distinct epigenetic mechanisms are correlated with high-frequency "switching" for APRT phenotypic expression in mouse embryonal carcinoma stem cells.Semantic proximity Read ↗

Telomerase Promoter Reprogramming and Interaction with General Transcription Factors in the Human Mesenchymal Stem CellSemantic proximity Read ↗

Inducible lncRNA transgenic mice reveal continual role of HOTAIR in promoting breast cancer metastasisSemantic proximity Read ↗

Silencing of mouse Aprt is a gradual process in differentiated cells.Semantic proximity Read ↗

Tetracycline-inducible expression systems with reduced basal activity in mammalian cellsSemantic proximity Read ↗

Double Strand Breaks Can Initiate Gene Silencing and SIRT1-Dependent Onset of DNA Methylation in an Exogenous Promoter CpG IslandSemantic proximity Read ↗

Understanding the relevance of epigenetic reprogramming for resistance to HDAC inhibitors in cancer cellsSemantic proximity Read ↗

Telomere Position Effect and Silencing of Transgenes near Telomeres in the MouseSemantic proximity Read ↗

Derangement of a factor upstream of RARalpha triggers the repression of a pleiotropic epigenetic network.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.