Article
Disrupted in Schizophrenia 1 and Nudel form a neurodevelopmentally regulated protein complex: implications for schizophrenia and other major neurological disorders.
Molecular and cellular neurosciences - 1 Jan 2004
Brandon N J, Handford E J, Schurov I, Rain J-C, Pelling M, Duran-Jimeniz B, Camargo L M, Oliver K R, Beher D, Shearman M S, Whiting P J
Abstract excerpt
Disrupted In Schizophrenia 1 (DISC1) was identified as a potential susceptibility gene for schizophrenia due to its disruption by a balanced t(1;11) (q42;q14) translocation, which has been shown to cosegregate with major psychiatric disease in a large Scottish family. We have demonstrated that DISC1 exists in a neurodevelopmentally regulated protein complex with Nudel. The complex is abundant at E17 and in early...
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