Article
Analysis of the catalytic domain of phosphatidylinositol 4-kinase type II.
The Journal of biological chemistry - 15 Nov 2002
Barylko Barbara, Wlodarski Pawel, Binns Derk D, Gerber Stefan H, Earnest Svetlana, Sudhof Thomas C, Grichine Nikolai, Albanesi Joseph P
Abstract excerpt
Phosphatidylinositol (PtdIns) 4-kinases catalyze the conversion of PtdIns to PtdIns 4-phosphate, the major precursor of phosphoinositides that regulates a vast array of cellular processes. Based on enzymatic differences, two classes of PtdIns 4-kinase have been distinguished termed Types II and III. Type III kinases, which belong to the phosphatidylinositol (PI) 3/4-kinase family, have been extensively...
Topics
- 1-Phosphatidylinositol 4-Kinase
- Actins
- Amino Acid Sequence
- Androstadienes
- Animals
- Catalysis
- Catalytic Domain
- Cell Line
- Cell Membrane
- Cloning, Molecular
- Dose-Response Relationship, Drug
- Drosophila
- Enzyme Inhibitors