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Article

Biophysical and Structural Characterization of Novel RAS-Binding Domains (RBDs) of PI3Kα and PI3Kγ.

Journal of molecular biology - 16 Apr 2021

Martinez Nicholas G, Thieker David F, Carey Leiah M, Rasquinha Juhi A, Kistler Samantha K, Kuhlman Brian A, Campbell Sharon L

Abstract excerpt

Phosphatidylinositol-3-kinases (PI3Ks) are lipid kinases that phosphorylate phosphatidylinositol 4,5-bisphosphate to generate a key lipid second messenger, phosphatidylinositol 3,4,5-bisphosphate. PI3Kα and PI3Kγ require activation by RAS proteins to stimulate signaling pathways that control cellular growth, differentiation, motility and survival. Intriguingly, RAS binding to PI3K isoforms likely differ, as RAS...

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Identifiers

PMID: 33539876
DOI: 10.1016/j.jmb.2021.166838
PMCID: PMC8005443

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