Article
Alleles of polymorphic sites that correspond to hyperactive variants of CYP1B1 protein are significantly less frequent in Japanese as compared to American and German populations.
Human mutation - 1 Jun 2003
Sasaki Masahiro, Tanaka Yuichiro, Kaneuchi Masanori, Sakuragi Noriaki, Dahiya Rajvir
Abstract excerpt
CYP1B1 metabolites receive particular attention because of their causative role in malignant transformation of various steroid-related organs. Rare variants at residues c.701, c.1294 and c.1358 of CYP1B1 gene result in hyper-activity of protein and can lead to a higher susceptibility to estrogen-related cancers. However, in Japan, the incidences of estrogen-related cancers are remarkably lower than in Western...
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