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Article

CYP1B1 and hormone-induced cancer.

Cancer letters - 1 Nov 2012

Gajjar Ketan, Martin-Hirsch Pierre L, Martin Francis L

Abstract excerpt

Cancers in hormone-responsive tissues (e.g., breast, ovary, endometrium, prostate) occur at high incidence rates worldwide. However, their genetic basis remains poorly understood. Studies to date suggest that endogenous/exogenous oestrogen and environmental carcinogens may play a role in development and/or progression of hormone-induced cancers via oxidative oestrogen metabolism. Cytochrome P450 1B1 is a key...

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PMID: 22561558
DOI: 10.1016/j.canlet.2012.04.021

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