Article
A functional C-G polymorphism in the CYP7B1 promoter region and its different distribution in Orientals and Caucasians.
The pharmacogenomics journal - 1 Jan 2004
Jakobsson J, Karypidis H, Johansson J-E, Roh H-K, Rane A, Ekström L
Abstract excerpt
Cytochrome P450 (CYP) 7B1 is involved in many metabolic processes including androgen metabolism. Genetic variation in the CYP7B1 gene may play a role in predisposition to prostate cancer. Here, we screened the human CYP7B1 gene for possible polymorphisms. Only one single polymorphism was detected, a C-G change in the promoter -104 base pair from the transcription start site. The allele frequency was investigated...
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