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Article

Association of CYP1B1 genetic polymorphism with incidence to breast and lung cancer.

Pharmacogenetics - 1 Feb 2000

Watanabe J, Shimada T, Gillam E M, Ikuta T, Suemasu K, Higashi Y, Gotoh O, Kawajiri K

Abstract excerpt

Cytochrome P450 1B1 (CYP1B1) participates in the metabolic activation of a number of procarcinogens including benzo[a]pyrene and the hydroxylation of 17beta-estradiol at the C-4 position. In this study, we investigated the association between CYP1B1 genetic polymorphism and breast or lung cancer incidence. The Ala-Ser polymorphism at codon 119 in presumed substrate recognition site 1 was significantly associated...

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Identifiers

PMID: 10739169
DOI: 10.1097/00008571-200002000-00004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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