Article
Evaluation of approaches to identify associated SNPs that explain the linkage evidence in nuclear families with affected siblings.
Human heredity - 1 Jan 2010
Chen Ming-Huei, Van Eerdewegh Paul, Vincent Quentin B, Alcais Alexandre, Abel Laurent, Dupuis Josée
Abstract excerpt
Linkage analysis is often followed by association mapping to localize disease variants. In this paper, we evaluate approaches to determine how much of the observed linkage evidence, namely the identity-by-descent (IBD) sharing at the linkage peak, is explained by associated SNPs. We study several methods: Homozygote Sharing Tests (HST), Genotype Identity-by-Descent Sharing Test (GIST), and a permutation approach....
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