Transmission and accumulation of CTL escape variants drive negative associations between HIV polymorphisms and HLA.

doi:10.1084/jem.20041455

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Article

Transmission and accumulation of CTL escape variants drive negative associations between HIV polymorphisms and HLA.

The Journal of experimental medicine - 21 Mar 2005

Leslie Alasdair, Kavanagh Daniel, Honeyborne Isobella, Pfafferott Katja, Edwards Charles, Pillay Tilly, Hilton Louise, Thobakgale Christina, Ramduth Danni, Draenert Rika, Le Gall Sylvie, Luzzi Graz, Edwards Anne, Brander Christian, Sewell Andrew K, Moore Sarah, Mullins James, Moore Corey, Mallal Simon, Bhardwaj Nina, Yusim Karina, Phillips Rodney, Klenerman Paul, Korber Bette, Kiepiela Photini, Walker Bruce, Goulder Philip

Abstract excerpt

Human immunodeficiency virus (HIV)-1 amino acid sequence polymorphisms associated with expression of specific human histocompatibility leukocyte antigen (HLA) class I alleles suggest sites of cytotoxic T lymphocyte (CTL)-mediated selection pressure and immune escape. The associations most frequently observed are between expression of an HLA class I molecule and variation from the consensus sequence. However, a...

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PMID: 15781581
DOI: 10.1084/jem.20041455
PMCID: PMC2213090

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