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Article

Molecular evolution of human immunodeficiency virus type 1 upon transmission between human leukocyte antigen disparate donor-recipient pairs.

PloS one - 18 Jun 2008

Navis Marjon, Matas Diana Edo, Rachinger Andrea, Koning Fransje A, van Swieten Peter, Kootstra Neeltje A, Schuitemaker Hanneke

Abstract excerpt

BACKGROUND: To address evolution of HIV-1 after transmission, we studied sequence dynamics in and outside predicted epitopes of cytotoxic T lymphocytes (CTL) in subtype B HIV-1 variants that were isolated from 5 therapy-naive horizontal HLA-disparate donor-recipient pairs from the Amsterdam Cohort Studies on HIV-1 infection and AIDS. METHODOLOGY/PRINCIPAL FINDINGS: In the first weeks after transmission, the...

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Identifiers

PMID: 18560583
DOI: 10.1371/journal.pone.0002422
PMCID: PMC2409968

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