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Article

FoxO1 induces Ikaros splicing to promote immunoglobulin gene recombination

30 Jan 2012

Abstract excerpt

Somatic rearrangement of immunoglobulin (Ig) genes is a key step during B cell development. Using pro-B cells lacking the phosphatase Pten (phosphatase and tensin homolog), which negatively regulates phosphoinositide-3-kinase (PI3K) signaling, we show that PI3K signaling inhibits Ig gene rearrangement by suppressing the expression of the transcription factor Ikaros. Further analysis revealed that the...

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PMID: 22291095
DOI: 10.1084/jem.20110216

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FoxO1 induces Ikaros splicing to promote immunoglobulin gene recombinationPMID 22291095Read ↗

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