Article
The Justy mutation identifies Gon4-like as a gene that is essential for B lymphopoiesis.
The Journal of experimental medicine - 5 Jul 2010
Lu Ping, Hankel Isaiah L, Knisz Judit, Marquardt Andreas, Chiang Ming-Yi, Grosse Johannes, Constien Rainer, Meyer Thomas, Schroeder Andreas, Zeitlmann Lutz, Al-Alem Umaima, Friedman Ann D, Elliott Eric I, Meyerholz David K, Waldschmidt Thomas J, Rothman Paul B, Colgan John D
Abstract excerpt
A recessive mutation named Justy was found that abolishes B lymphopoiesis but does not impair other major aspects of hematopoiesis. Transplantation experiments showed that homozygosity for Justy prevented hematopoietic progenitors from generating B cells but did not affect the ability of bone marrow stroma to support B lymphopoiesis. In bone marrow from mutant mice, common lymphoid progenitors and pre-pro-B cells...
Topics
- Animals
- B-Lymphocytes
- Base Sequence
- Co-Repressor Proteins
- DNA-Binding Proteins
- Gene Expression Regulation
- Hematopoietic Stem Cells
- Lymphopoiesis
- Male