Cutting edge: lack of peripheral B cells and severe agammaglobulinemia in mice simultaneously lacking Bruton's tyrosine kinase and the B cell-specific transcriptional coactivator OBF-1.

Abstract excerpt

OBF-1 is a B cell-restricted transcriptional coactivator that is recruited to octamer-containing promoters by interacting with the POU domain of Oct-1 or Oct-2. We have shown earlier that mice lacking OBF-1 were dramatically impaired in their ability to mount humoral immune responses and did not develop germinal centers in the spleen; however, they had a largely normal B cell development in the bone marrow. In...

Topics

• Agammaglobulinaemia Tyrosine Kinase
• Agammaglobulinemia
• Animals
• B-Lymphocytes
• Cell Differentiation
• Female
• Gene Expression Regulation
• Gene Expression Regulation, Developmental
• Genes, Immunoglobulin
• Genetic Linkage