Article
The Ets factor Spi-B is a direct critical target of the coactivator OBF-1.
Proceedings of the National Academy of Sciences of the United States of America - 1 Aug 2006
Bartholdy Boris, Du Roure Camille, Bordon Alain, Emslie Dianne, Corcoran Lynn M, Matthias Patrick
Abstract excerpt
OBF-1 (Bob.1, OCA-B) is a lymphoid-specific transcriptional coactivator that associates with the transcription factors Oct-1 or Oct-2 on the conserved octamer element present in the promoters of several ubiquitous and lymphoid-specific genes. OBF-1-deficient mice have B cell-intrinsic defects, lack germinal centers, and have severely impaired immune responses to T cell-dependent antigens. Crucial genes that are...
Topics
- Animals
- DNA-Binding Proteins
- Humans
- In Situ Hybridization
- Mice
- Mice, Transgenic
- Oligonucleotide Array Sequence Analysis
- Phenotype
- Proto-Oncogene Proteins c-ets
- Receptors, Antigen, B-Cell
- Signal Transduction
- T-Lymphocytes
- Trans-Activators