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Article

The Ets factor Spi-B is a direct critical target of the coactivator OBF-1.

Proceedings of the National Academy of Sciences of the United States of America - 1 Aug 2006

Bartholdy Boris, Du Roure Camille, Bordon Alain, Emslie Dianne, Corcoran Lynn M, Matthias Patrick

Abstract excerpt

OBF-1 (Bob.1, OCA-B) is a lymphoid-specific transcriptional coactivator that associates with the transcription factors Oct-1 or Oct-2 on the conserved octamer element present in the promoters of several ubiquitous and lymphoid-specific genes. OBF-1-deficient mice have B cell-intrinsic defects, lack germinal centers, and have severely impaired immune responses to T cell-dependent antigens. Crucial genes that are...

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Identifiers

PMID: 16861304
DOI: 10.1073/pnas.0509430103
PMCID: PMC1513538

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The Ets factor Spi-B is a direct critical target of the coactivator OBF-1.PMID 16861304Read ↗

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The B lymphocyte-specific coactivator BOB.1/OBF.1 is required at multiple stages of B-cell development.Semantic proximity Read ↗

The OBF-1 gene locus confers B cell-specific transcription by restricting the ubiquitous activity of its promoter.Semantic proximity Read ↗

Inducible Expression and Phosphorylation of Coactivator BOB.1/OBF.1 in T CellsSemantic proximity Read ↗

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B-Cell coactivator OBF-1 exhibits unusual transcriptional properties and functions in a DNA-bound Oct-1-dependent fashion.Semantic proximity Read ↗

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Targeting transcriptional coregulator OCA-B/Pou2af1 blocks activated autoreactive T cells in the pancreas and type 1 diabetes.Semantic proximity Read ↗

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