Article
The C-terminal region of Ge-1 presents conserved structural features required for P-body localization.
RNA (New York, N.Y.) - 1 Oct 2008
Jinek Martin, Eulalio Ana, Lingel Andreas, Helms Sigrun, Conti Elena, Izaurralde Elisa
Abstract excerpt
The removal of the 5' cap structure by the DCP1-DCP2 decapping complex irreversibly commits eukaryotic mRNAs to degradation. In human cells, the interaction between DCP1 and DCP2 is bridged by the Ge-1 protein. Ge-1 contains an N-terminal WD40-repeat domain connected by a low-complexity region to a conserved C-terminal domain. It was reported that the C-terminal domain interacts with DCP2 and mediates Ge-1...
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