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Article

Decapping reaction of mRNA requires Dcp1 in fission yeast: its characterization in different species from yeast to human.

Journal of biochemistry - 1 Dec 2004

Sakuno Takeshi, Araki Yasuhiro, Ohya Yuriko, Kofuji Satoshi, Takahashi Shinya, Hoshino Shin-ichi, Katada Toshiaki

Abstract excerpt

Cleavage of the 5'-cap structure is involved in the major 5'-to-3' and nonsense-mediated mRNA decay pathways, and the protein complex consisting of Dcp1 and Dcp2 has been identified as the species responsible for the decapping reaction in Saccharomyces cerevisiae and human. Although in vitro studies indicate that Dcp2 is catalytically an active component, the role of Dcp1 in the decapping reaction remains to be...

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PMID: 15671491
DOI: 10.1093/jb/mvh190

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Decapping reaction of mRNA requires Dcp1 in fission yeast: its characterization in different species from yeast to human.PMID 15671491Read ↗

Two related proteins, Edc1p and Edc2p, stimulate mRNA decapping in Saccharomyces cerevisiae.Semantic proximity Read ↗

Human DCP1 is crucial for mRNA decapping and possesses paralog-specific gene regulating functionsSemantic proximity Read ↗

Control of mRNA decapping by positive and negative regulatory elements in the Dcp2 C-terminal domain.Semantic proximity Read ↗

Analysis of mutations in the yeast mRNA decapping enzyme.Semantic proximity Read ↗

New insights into the control of mRNA decapping.Semantic proximity Read ↗

Identification and analysis of the interaction between Edc3 and Dcp2 in Saccharomyces cerevisiae.Semantic proximity Read ↗

Non-redundant roles for the human mRNA decapping cofactor paralogs DCP1a and DCP1bSemantic proximity Read ↗

Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay.Semantic proximity Read ↗

Crystal structure of Dcp1p and its functional implications in mRNA decapping.Semantic proximity Read ↗

Scavenger decapping activity facilitates 5' to 3' mRNA decay.Semantic proximity Read ↗

Upf1p, Nmd2p, and Upf3p regulate the decapping and exonucleolytic degradation of both nonsense-containing mRNAs and wild-type mRNAs.Semantic proximity Read ↗

Arabidopsis DCP2, DCP1, and VARICOSE form a decapping complex required for postembryonic development.Semantic proximity Read ↗

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