Article
Cyclin-dependent kinase 2 (cdk2) in the murine Cdc2 kinase TS mutant.
Somatic cell and molecular genetics - 1 Sept 1992
Yasuda H, Nakata T, Kamijo M, Honda R, Nakamura M, Ninomiya-Tsuji J, Yamashita M, Nagahama Y, Ohba Y
Abstract excerpt
Kinases of the mammalian cdc2 family including cdk2 (cyclin-dependent kinase 2) are thought to be involved in both the G2/M transition and DNA replication. To investigate the role of cdc2 kinase and cdk2 in cell cycle progression, murine tsFT210 cells bearing a temperature-sensitive cdc2 mutation were used. These kinases were purified by column chromatography, using a peptide with the consensus phosphorylation...
Topics
- Animals
- CDC2 Protein Kinase
- CDC2-CDC28 Kinases
- Cell Cycle
- Cyclin-Dependent Kinase 2
- Cyclin-Dependent Kinases
- Cyclins
- Hot Temperature
- Mice
- Mutation
- Protein Kinases