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Article

Cloning of a human cDNA encoding a CDC2-related kinase by complementation of a budding yeast cdc28 mutation.

Proceedings of the National Academy of Sciences of the United States of America - 15 Oct 1991

Ninomiya-Tsuji J, Nomoto S, Yasuda H, Reed S I, Matsumoto K

Abstract excerpt

We have cloned two different human cDNAs that can complement cdc28 mutations of budding yeast Saccharomyces cerevisiae. One corresponds to a gene encoding human p34CDC2 kinase, and the other to a gene (CDK2; cell division kinase) that has not been characterized previously. The CDK2 protein is highly homologous to p34CDC2 kinase (65% identical) and more significantly is homologous to Xenopus Eg1 kinase (89%...

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Identifiers

PMID: 1717994
DOI: 10.1073/pnas.88.20.9006
PMCID: PMC52640

Genes

CDK2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Cloning of a human cDNA encoding a CDC2-related kinase by complementation of a budding yeast cdc28 mutation.PMID 1717994Read ↗

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