Cloning of a human cDNA encoding a CDC2-related kinase by complementation of a budding yeast cdc28 mutation.

doi:10.1073/pnas.88.20.9006

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Article

Cloning of a human cDNA encoding a CDC2-related kinase by complementation of a budding yeast cdc28 mutation.

Proceedings of the National Academy of Sciences of the United States of America - 15 Oct 1991

Ninomiya-Tsuji J, Nomoto S, Yasuda H, Reed S I, Matsumoto K

Abstract excerpt

We have cloned two different human cDNAs that can complement cdc28 mutations of budding yeast Saccharomyces cerevisiae. One corresponds to a gene encoding human p34CDC2 kinase, and the other to a gene (CDK2; cell division kinase) that has not been characterized previously. The CDK2 protein is highly homologous to p34CDC2 kinase (65% identical) and more significantly is homologous to Xenopus Eg1 kinase (89%...

Topics

Alleles
Amino Acid Sequence
Animals
Base Sequence
Blotting, Northern
CDC2 Protein Kinase
Cell Line
Cloning, Molecular
DNA
Genetic Complementation Test
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Kinetics

Molecular Sequence Data

Mutation

Plasmids

Poly A

RNA

RNA, Messenger

Source

Open in PubMed Open full text

Identifiers

PMID: 1717994
DOI: 10.1073/pnas.88.20.9006
PMCID: PMC52640

Genes

CDK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1717994-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Cloning of a human cDNA encoding a CDC2-related kinase by complementation of a budding yeast cdc28 mutation.PMID 1717994Read ↗

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