Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Requirement for p34cdc2 kinase is restricted to mitosis in the mammalian cdc2 mutant FT210.

The Journal of cell biology - 1 Jun 1992

Hamaguchi J R, Tobey R A, Pines J, Crissman H A, Hunter T, Bradbury E M

Abstract excerpt

The mouse FT210 cell line is a temperature-sensitive cdc2 mutant. FT210 cells are found to arrest specifically in G2 phase and unlike many alleles of cdc2 and cdc28 mutants of yeasts, loss of p34cdc2 at the nonpermissive temperature has no apparent effect on cell cycle progression through the G1 and S phases of the division cycle. FT210 cells and the parent wild-type FM3A cell line each possess at least three...

Topics

Amino Acid Sequence
Animals
CDC2 Protein Kinase
Cell Line
Chromatography
Cyclins
Immunoblotting
Interphase
Maturation-Promoting Factor
Mice
Mitosis
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Peptide Fragments

Peptides

S Phase

Temperature

Source

Open in PubMed Open full text

Identifiers

PMID: 1533642
DOI: 10.1083/jcb.117.5.1041
PMCID: PMC2289476

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1533642-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Requirement for p34cdc2 kinase is restricted to mitosis in the mammalian cdc2 mutant FT210.PMID 1533642Read ↗

The FT210 cell line is a mouse G2 phase mutant with a temperature-sensitive CDC2 gene product.Semantic proximity Read ↗

A point mutation in C-terminal region of cdc2 kinase causes a G2-phase arrest in a mouse temperature-sensitive FM3A cell mutant.Semantic proximity Read ↗

Mouse development and cell proliferation in the absence of D-cyclins.Semantic proximity Read ↗

Mitotic Regulation of Ribosomal S6 Kinase 1 Involves Ser/Thr, Pro Phosphorylation of Consensus and Non-consensus Sites by Cdc2Semantic proximity Read ↗

Cdk2 and Cdk4 cooperatively control the expression of Cdc2.Semantic proximity Read ↗

Cyclin-dependent kinase 2 (cdk2) in the murine Cdc2 kinase TS mutant.Semantic proximity Read ↗

Cold-sensitive mutants of p34cdc2 that suppress a mitotic catastrophe phenotype in fission yeast.Semantic proximity Read ↗

The function of the chicken p34CDC2 protein kinase in fission yeast is cold sensitive for cell cycle progression through the G1 phase and temperature sensitive for traversal of mitosis.Semantic proximity Read ↗

Distinct pools of cdc25C are phosphorylated on specific TP sites and differentially localized in human mitotic cells.Semantic proximity Read ↗

A mouse cdc25 homolog is differentially and developmentally expressed.Semantic proximity Read ↗

Regulation of p34cdc2 protein kinase activity by phosphorylation and cyclin binding.Semantic proximity Read ↗

<i>Cdk</i> family genes are expressed not only in dividing but also in terminally differentiated mouse germ cells, suggesting their possible function during both cell division and differentiationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.