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Article

Induction of p53 and p21 proteins by gamma radiation in skin fibroblasts derived from breast cancer patients.

International journal of radiation oncology, biology, physics - 1 Feb 2004

Torres Martha, Al-Buhairi Muneera, Alsbeih Ghazi

Abstract excerpt

PURPOSE: To test the hypothesis that breast cancer patients could have a predisposing defect in the induction of TP53 tumor suppressor protein (known as p53) that could be a marker of genetic instability and increased cancer susceptibility. The accumulation of p53 was triggered by ionizing radiation, and its transcriptional activity was estimated from the induction of CDKN1A (known as p21). METHODS AND MATERIALS:...

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Identifiers

PMID: 14751518
DOI: 10.1016/j.ijrobp.2003.09.062

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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