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Article

Degradation of p21CDKN1A after DNA damage is independent of type of lesion, and is not required for DNA repair.

DNA repair - 4 Jul 2009

Savio Monica, Coppa Tania, Cazzalini Ornella, Perucca Paola, Necchi Daniela, Nardo Tiziana, Stivala Lucia A, Prosperi Ennio

Abstract excerpt

The inhibitor of cyclin-dependent kinases p21CDKN1A plays a fundamental role in several pathways involved in the DNA damage response, like checkpoint-mediated cell cycle arrest, transcription, apoptosis, and DNA repair. Although p21 protein level is regulated by proteasomal degradation, the relationship of this process with DNA repair pathways is not yet clear. In addition, the role of protein/protein interaction...

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Source

Identifiers

PMID: 19321391
DOI: 10.1016/j.dnarep.2009.02.005

Genes

PCNA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Degradation of p21CDKN1A after DNA damage is independent of type of lesion, and is not required for DNA repair.PMID 19321391Read ↗

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