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Breast Carcinoma–Associated Fibroblasts and Their Counterparts Display Neoplastic-Specific Changes

15 Apr 2008

Abstract excerpt

It has become clear that the initiation and progression of carcinomas depend not only on alterations in epithelial cells, but also on changes in their microenvironment. To identify these changes, we have undertaken cellular and molecular characterization of carcinoma-associated fibroblasts (CAF) and their tumor counterpart fibroblasts (TCF) isolated from 12 breast cancer patients. Normal breast fibroblasts (NBF)...

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PMID: 18413739
DOI: 10.1158/0008-5472.can-08-0192

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