Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

p21(WAF1/CIP1) response to genotoxic agents in wild-type TP53 expressing breast primary tumours.

Oncogene - 9 Jan 1997

Guillot C, Falette N, Paperin M P, Courtois S, Gentil-Perret A, Treilleux I, Ozturk M, Puisieux A

Abstract excerpt

Functional inactivation of the wild-type p53 protein has been described in different human cancers. Since a significant proportion of breast tumours express wild-type TP53, the p53 antiproliferative activity could be inactivated in transformed mammary epithelial cells by a mechanism independent on structural alteration of the gene. To test this hypothesis, we analysed the p53 activity in primary breast tumour...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Breast Neoplasms
Share to Cyclin-Dependent Kinase Inhibitor p21

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cyclins

Share to Doxorubicin

Share to Genes, p53

Share to Mutation

Share to Tumor Cells, Cultured

Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 9010231
DOI: 10.1038/sj.onc.1200803

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

p21(WAF1/CIP1) response to genotoxic agents in wild-type TP53 expressing breast primary tumours.PMID 9010231Read ↗

TP53 status and response to chemotherapy in breast cancer.Semantic proximity Read ↗

p53 dependent cell-cycle arrest triggered by chemotherapy in xenografted breast tumors.Semantic proximity Read ↗

The Cyclin-Dependent Kinase Inhibitor p21CDKN1A as a Target of Anti-Cancer DrugsSemantic proximity Read ↗

Relationship between abnormal p53 protein and failure to express p21 protein in human breast carcinomas.Semantic proximity Read ↗

Characterization of human breast cancer cell lines for the studies on p53 in chemical carcinogenesis.Semantic proximity Read ↗

The role of TP53 in breast cancer development.Semantic proximity Read ↗

Role of p53 mutations, protein function and DNA damage for the radiosensitivity of human tumour cellsSemantic proximity Read ↗

PRIMA-1 cytotoxicity correlates with nucleolar localization and degradation of mutant p53 in breast cancer cells.Semantic proximity Read ↗

Is TP53 dysfunction required for BRCA1-associated carcinogenesis?Semantic proximity Read ↗

Normal p53 status and function despite the development of drug resistance in human breast cancer cells.Semantic proximity Read ↗

Two variants of the CIP1/WAF1 gene occur together and are associated with human cancer.Semantic proximity Read ↗

p53 over‐expression identifies a subset of nodal peripheral T‐cell lymphomas with a distinctive biological profile and poor clinical outcomeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.