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Article

Radiosensitivity in breast cancer assessed by the histone γ-H2AX and 53BP1 foci

24 Apr 2013

Abstract excerpt

BACKGROUND: High expression of constitutive histone γ-H2AX, a sensitive marker of DNA damage, might be indicative of defective DNA repair pathway or genomic instability. 53BP1 (p53-binding protein 1) is a conserved checkpoint protein with properties of a DNA double-strand breaks sensor. This study explores the relationship between the clinical radiosensitivity of tumor patients and the expression/induction of...

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PMID: 23617930
DOI: 10.1186/1748-717x-8-98

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