Article
The p53-mediated DNA damage response to ionizing radiation in fibroblasts from ataxia-without-telangiectasia patients.
International journal of radiation biology - 1 Sept 1998
Jongmans W, Vuillaume M, Kleijer W J, Lakin N D, Hall J
Abstract excerpt
PURPOSE: To assess the functionality of the p53-mediated pathway, activated by the ataxia-telangiectasia gene product (ATM) in response to ionizing radiation, in cells derived from four ataxia-without-telangiectasia patients. These patients exhibit cerebellar ataxia and cellular abnormalities tha...
Topics
- Ataxia
- Ataxia Telangiectasia Mutated Proteins
- Blotting, Northern
- Cell Cycle Proteins
- Cells, Cultured
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclins
- DNA Damage
- DNA-Binding Proteins
- Fibroblasts
- Gene Expression
- Humans
- Immunoblotting
- Mutation
- Phenotype
- Protein Serine-Threonine Kinases
- Proteins
- RNA, Messenger