Article
A rapid somatic genotoxicity assay in Drosophila melanogaster using multiple mutant mutagen-sensitive (mus) strains.
Mutagenesis - 1 Nov 1992
Henderson D S, Grigliatti T A
Abstract excerpt
Mutagen-sensitive (mus) mutations in Drosophila melanogaster render developing flies hypersensitive to the lethal effects of DNA-damaging agents. In principle, multiply mutant mus strains might then serve as sensitive in vivo indicators of a wide range of mutagens and genotoxic carcinogens. As a...
Topics
- Animals
- DNA Damage
- DNA Repair
- Drosophila melanogaster
- Drug Resistance
- Evaluation Studies as Topic
- Female
- Heterozygote
- Homozygote
- Male
- Methyl Methanesulfonate
- Mutagenicity Tests