Article
In vivo DNA deletion assay to detect environmental and genetic predisposition to cancer.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2004
Reliene Ramune, Bishop Alexander J R, Aubrecht Jiri, Schiestl Robert H
Abstract excerpt
Large-scale genomic rearrangements such as DNA deletions play a role in the etiology of cancer. The frequency of DNA deletions can be elevated by exposure to carcinogens or by mutations in genes involved in the maintenance of genomic integrity. The in vivo DNA deletion assay allows a visual detection of deletion events within the pink-eyed unstable (pun) locus in developing mouse embryos. A deletion of one copy...
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