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Article

mus308 mutants of Drosophila exhibit hypersensitivity to DNA cross-linking agents and are defective in a deoxyribonuclease.

Genetics - 1 Aug 1990

Boyd J B, Sakaguchi K, Harris P V

Abstract excerpt

Mutagen-sensitive strains that identify 16 different Drosophila genes have been screened for alterations in DNA metabolic enzymes. A characteristic defect in an acid-active deoxyribonuclease was observed in strains carrying the six available mutant alleles of the mus308 gene. Since that enzyme is detected at normal levels in a mutant strain that is deficient in the previously identified enzymes DNase 1 and DNase...

Topics

Animals
Cross-Linking Reagents
DNA
DNA Repair
Deoxyribonucleases
Drosophila
Ficusin
Genes
Mechlorethamine
Mutagens
Mutation

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Identifiers

PMID: 2397884
DOI: 10.1093/genetics/125.4.813
PMCID: PMC1204107

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2397884-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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mus308 mutants of Drosophila exhibit hypersensitivity to DNA cross-linking agents and are defective in a deoxyribonuclease.PMID 2397884Read ↗

Characterization of the mus308 gene in Drosophila melanogaster.Semantic proximity Read ↗

The mus308 locus of Drosophila melanogaster is implicated in the bypass of ENU-induced O-alkylpyrimidine adducts.Semantic proximity Read ↗

DNA repair defects and other (mus)takes in Drosophila melanogaster.Semantic proximity Read ↗

A large-scale screen for mutagen-sensitive loci in Drosophila.Semantic proximity Read ↗

A rapid somatic genotoxicity assay in Drosophila melanogaster using multiple mutant mutagen-sensitive (mus) strains.Semantic proximity Read ↗

Analyzing double-strand repair events in Drosophila.Semantic proximity Read ↗

A new DNA polymerase species from Drosophila melanogaster: a probable mus308 gene product.Semantic proximity Read ↗

Third-chromosome mutagen-sensitive mutants of Drosophila melanogaster.Semantic proximity Read ↗

The Drosophila mus 308 gene product, implicated in tolerance of DNA interstrand crosslinks, is a nuclear protein found in both ovaries and embryos.Semantic proximity Read ↗

The mus206 gene of Drosophila melanogaster is required in the excision repair of alkylation-induced DNA lesions.Semantic proximity Read ↗

Re-evaluation of excision repair in the mus304, mus306 and mus308 mutants of Drosophila.Semantic proximity Read ↗

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