Nucleophilic selectivity of alkylating agents and their hypermutability in Drosophila as predictors of carcinogenic potency in rodents.

doi:10.1093/carcin/11.12.2211

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Article

Nucleophilic selectivity of alkylating agents and their hypermutability in Drosophila as predictors of carcinogenic potency in rodents.

Carcinogenesis - 1 Dec 1990

Vogel E W, Barbin A, Nivard M J, Bartsch H

Abstract excerpt

The nucleophilic selectivity (Swain-Scott s constant or initial 7-alkylguanine/O6-alkylguanine ratio in DNA) of 60 alkylating agents, mostly monofunctional or cross-linking was compared to their carcinogenic potency in rodents (median TD50 estimates) and to two genotoxicity indices in Drosophila:...

Topics

Alkylating Agents
Alkylation
Animals
Carcinogenicity Tests
Cross-Linking Reagents
DNA Repair
Drosophila
Mutagenicity Tests
Mutation
Rodentia

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