Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rapid, accurate genotyping of the common -alpha(4.2) thalassaemia deletion based on the use of denaturing HPLC.

Journal of clinical pathology - 1 Feb 2004

Ou-Yang H, Hua L, Mo Q H, Xu X M

Abstract excerpt

AIMS: To develop an alternative assay for specific genotyping of the -alpha(4.2) thalassaemia deletion based on the DNA sequence features surrounding the breakpoint. METHODS: The 5' and 3' ends of the breakpoint regions of the -alpha(4.2) allele and the normal homologous segments were sequenced i...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to alpha-Thalassemia
Share to Chromatography, High Pressure Liquid
Share to DNA Mutational Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Deletion

Share to Genetic Carrier Screening

Share to Genetic Testing

Share to Globins

Share to Sequence Alignment

Source

Open in PubMed Open full text

Identifiers

PMID: 14747441
DOI: 10.1136/jcp.2003.011130
PMCID: PMC1770208

Genes

SEA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14747441-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rapid, accurate genotyping of the common -alpha(4.2) thalassaemia deletion based on the use of denaturing HPLC.PMID 14747441Read ↗

Molecular assay of -alpha(3.7) and -alpha(4.2) deletions causing alpha-thalassemia by denaturing high-performance liquid chromatography.Semantic proximity Read ↗

Rapid, accurate genotyping of beta-thalassaemia mutations using a novel multiplex primer extension/denaturing high-performance liquid chromatography assay.Semantic proximity Read ↗

Validation of a reverse-hybridization StripAssay for the simultaneous analysis of common alpha-thalassemia point mutations and deletions.Semantic proximity Read ↗

A laboratory strategy for genotyping haemoglobin H disease in the Chinese.Semantic proximity Read ↗

Rapid detection of α-thalassaemia alleles of --(SEA)/, -α(3.7)/ and -α(4.2)/ using a dual labelling, self-quenching hybridization probe/melting curve analysis.Semantic proximity Read ↗

Detection of common deletional alpha-thalassemia-2 determinants by PCR.Semantic proximity Read ↗

Clinical validation of a single-tube PCR and reverse dot blot assay for detection of common α-thalassaemia and β-thalassaemia in ChineseSemantic proximity Read ↗

Analysis of variation in the human beta-globin gene cluster using a novel DHPLC technique.Semantic proximity Read ↗

Determination of the breakpoint and molecular diagnosis of a common α‐thalassaemia‐1 deletion in the Indian populationSemantic proximity Read ↗

Novel technique for rapid detection of alpha-globin gene mutations and deletions.Semantic proximity Read ↗

Detection and characterisation of beta-globin gene cluster deletions in Chinese using multiplex ligation-dependent probe amplification.Semantic proximity Read ↗

Molecular characterization and clinical presentation of HKαα and anti-HKαα alleles in southern Chinese subjects.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.