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Article

Analysis of variation in the human beta-globin gene cluster using a novel DHPLC technique.

Mutation research - 25 Apr 2002

Webster Matthew T, Wells R Spencer, Clegg John B

Abstract excerpt

We have implemented a technique combining allele-specific PCR (AS-PCR) and denaturing high-performance liquid chromatography (DHPLC) to identify new polymorphic variants within an intergenic region in the beta-globin cluster. This technique is applicable to the detection of new variants in genomic regions where variation is apportioned into distinct classes of haplotype. Duplexes for DHPLC analysis were created...

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Identifiers

PMID: 11934441
DOI: 10.1016/s0027-5107(02)00017-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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