A laboratory strategy for genotyping haemoglobin H disease in the Chinese.

doi:10.1136/jcp.2006.042242

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Article

A laboratory strategy for genotyping haemoglobin H disease in the Chinese.

Journal of clinical pathology - 1 Aug 2007

Chan Amy Yuk-Yin, So Chi-Chiu, Ma Edmond Shiu-Kwan, Chan Li-Chong

Abstract excerpt

BACKGROUND: The thalassaemias are the commonest blood disorders worldwide, with South East Asia and southern China as areas of high prevalence. Accurate diagnosis of these disorders helps in clinical management with improved outcome. METHODS: The alpha-globin genotypes of 100 Chinese patients in Hong Kong with haemoglobin H (Hb H) disease were characterised. Single-tube multiplex gap-PCR was used to detect...

Topics

Adolescent
Adult
Aged
Aged, 80 and over
Base Sequence
Child
Child, Preschool
Gene Deletion
Genotype
Globins
Hemoglobin H
Hemoglobins, Abnormal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hong Kong

Humans

Infant

Middle Aged

Mutation

Polymerase Chain Reaction

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Open in PubMed Open full text

Identifiers

PMID: 17018682
DOI: 10.1136/jcp.2006.042242
PMCID: PMC1994485

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