Article
Validation of a reverse-hybridization StripAssay for the simultaneous analysis of common alpha-thalassemia point mutations and deletions.
Clinical chemistry and laboratory medicine - 1 Jan 2007
Puehringer Helene, Najmabadi Hossein, Law Hai-Yang, Krugluger Walter, Viprakasit Vip, Pissard Serge, Baysal Erol, Taher Ali, Farra Chantal, Al-Ali Amein, Al-Ateeq Suad, Oberkanins Christian
Abstract excerpt
BACKGROUND: alpha-Thalassemia is a worldwide disease and considered to be a major public health problem in countries within the so-called thalassemia belt. The complex genetics of alpha-thalassemias requires diagnostic methods with the capacity to screen rapidly and accurately for common causative mutations. METHODS: We developed and validated a reverse-hybridization assay (Alpha-Globin StripAssay) for the rapid...
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