Article
Detection and characterisation of beta-globin gene cluster deletions in Chinese using multiplex ligation-dependent probe amplification.
Journal of clinical pathology - 1 Dec 2009
So C C, So A C Y, Chan A Y Y, Tsang S T Y, Ma E S K, Chan L C
Abstract excerpt
BACKGROUND: Deletions in the beta-globin cluster causing thalassaemia and hereditary persistence of fetal haemoglobin (HPFH) are uncommon and difficult to detect. Data in Chinese are very scarce. AIMS: To use a recently available technique to investigate the frequencies and nature of beta-globin cluster deletions in Chinese. METHODS: 106 subjects with phenotypes of thalassaemia or HPFH and suspected to have...
Topics
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Asian People
- Child
- Child, Preschool
- Female
- Fetal Hemoglobin
- Gene Deletion
- Genotype
- Hemoglobinopathies
- Humans
- Infant
- Male