Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular assay of -alpha(3.7) and -alpha(4.2) deletions causing alpha-thalassemia by denaturing high-performance liquid chromatography.

Clinical biochemistry - 1 Jul 2007

Hung Chia-Cheng, Lee Chien-Nan, Chen Chih-Ping, Jong Yuh-Jyh, Hsieh Wu-Shiun, Lin Win-Li, Su Yi-Ning, Hsu Su-Ming

Abstract excerpt

OBJECTIVES: alpha-Thalassemia, the most common single gene disorder in humans, is due to the absence of one (-alpha/alphaalpha) or both (--/alphaalpha) of the two functional alpha-globin genes (alpha1 and alpha2). The -alpha(3.7) and -alpha(4.2) single gene deletions are common in Southeast Asian populations. Southern blotting analysis and gap PCR assay are commonly used for the detection of such...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to alpha-Thalassemia
Share to Base Sequence

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chromatography, High Pressure Liquid

Share to Gene Deletion

Share to SEA gene

Share to Genotype

Share to Molecular Sequence Data

Share to Nucleic Acid Denaturation

Source

Identifiers

PMID: 17512924
DOI: 10.1016/j.clinbiochem.2007.03.018

Genes

SEA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular assay of -alpha(3.7) and -alpha(4.2) deletions causing alpha-thalassemia by denaturing high-performance liquid chromatography.PMID 17512924Read ↗

Identification of double heterozygous -α 4.2Ⅰ /-α 4.2Ⅱ using third-generation sequencingSemantic proximity Read ↗

Third-generation sequencing identified a novel complex variant in a patient with rare alpha-thalassemia.Semantic proximity Read ↗

[Detection of common deletions and mutations causing α-thalassemia in Southeast Asians and Southern Chinese with denaturing high performance liquid chromatography].Semantic proximity Read ↗

Rapid, accurate genotyping of the common -alpha(4.2) thalassaemia deletion based on the use of denaturing HPLC.Semantic proximity Read ↗

Identification of a novel 10.3 kb deletion causing α0-thalassemia by third-generation sequencing: Pedigree analysis and genetic diagnosis.Semantic proximity Read ↗

A versatile denaturing HPLC approach for human beta-globin gene mutation screening.Semantic proximity Read ↗

First clinical and molecular characterization of two rare complex β-globin variants in Chinese population using third generation sequencing.Semantic proximity Read ↗

Setup of a Protocol of Molecular Diagnosis of β-Thalassemia Mutations in Tunisia using Denaturing High-Performance Liquid Chromatography (DHPLC).Semantic proximity Read ↗

The -α3.7III subtype of α+-thalassemia was identified in China.Semantic proximity Read ↗

Case report: Long-read sequencing identified a novel 14.9-kb deletion of the α-globin gene locus in a family with α-thalassemia in ChinaSemantic proximity Read ↗

Identification of a Novel 7-bp Deletion in the α-Globin Gene Cluster in One Chinese Family.Semantic proximity Read ↗

Rapid genotyping of known mutations and polymorphisms in beta-globin gene based on the DHPLC profile patterns of homoduplexes and heteroduplexes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.