Article
RNAi-mediated Hip1R silencing results in stable association between the endocytic machinery and the actin assembly machinery.
Molecular biology of the cell - 1 Apr 2004
Engqvist-Goldstein Asa E Y, Zhang Claire X, Carreno Sebastien, Barroso Consuelo, Heuser John E, Drubin David G
Abstract excerpt
Actin filaments transiently associate with the endocytic machinery during clathrin-coated vesicle formation. Although several proteins that might mediate or regulate this association have been identified, in vivo demonstration of such an activity has not been achieved. Huntingtin interacting protein 1R (Hip1R) is a candidate cytoskeletal-endocytic linker or regulator because it binds to clathrin and actin. Here,...
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