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Article

Structural definition of the F-actin-binding THATCH domain from HIP1R.

Nature structural & molecular biology - 1 Feb 2006

Brett Tom J, Legendre-Guillemin Valerie, McPherson Peter S, Fremont Daved H

Abstract excerpt

Huntingtin-interacting protein-1 related (HIP1R) has a crucial protein-trafficking role, mediating associations between actin and clathrin-coated structures at the plasma membrane and trans-Golgi network. Here, we characterize the F-actin-binding region of HIP1R, termed the talin-HIP1/R/Sla2p actin-tethering C-terminal homology (THATCH) domain. The 1.9-A crystal structure of the human HIP1R THATCH core reveals a...

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Source

Identifiers

PMID: 16415883
DOI: 10.1038/nsmb1043

Genes

HIP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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